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| Item | Description |
| Poké Ball | This ball will capture Pokemon weakened in battle. |
| Great Ball | Slightly better than Pokéball |
| Ultra Ball | Slightly better than Great ball |
| Safari Ball | You need this to capture Safari Zone Pokemon. |
| Master Ball | This ball will capture any Wild Pokemon. |
| Antidote | Cures poison |
| Ice Heal | Heals frostbite |
| Awakening | Wakes up a dozing Pokemon. |
| Paralyze Heal | Heals paralyzed Pokemon. |
| Full Heal | Cures all conditions |
| Potion | Restores some of your Pokemon's HP |
| Super Potion | Restores more of your Pokemon's HP. |
| Hyper Potion | Restores more HP than Super Potion. |
| Max Potion | Completely restores HP. |
| Full Restore | Completely restores HP, and heals all conditions. |
| Revive | Revives a fallen Pokemon. |
| Max Revive | Revives a fallen Pokemon, and completely restores HP. |
| Rare Candy | Increases a Pokemon's level by one. |
| HP Up | Increases Pokemon's HP level. |
| PP Up | Increases Pokemons PP (Power Points) level. |
| Protein | Increases Attack Power. |
| Iron | Increases Defense. |
| Carbos | Increases Speed. |
| Calcium | Increases Special Ability. |
| X Attack | Increases Attack during a battle. |
| X Defend | Increases Defense during a battle. |
| X Special | Increases Special only during battle. |
| X Speed | Increases Speed during battle. |
| X Accuracy | Increases Accuracy in a battle. |
| Guard Special | Disables enemy Pokemon's Special Attack. |
| Dire Hit | Increases your Pokemon's attack in battle. |
| Bike | Use this to travel quickly. |
| Escape Rope | Use this to escape a cave. |
| Super/Max/Normal Repel | Keep weak Pokemon from attacking. |
| Poké Doll | A popular doll. Allows you to run away. |
| Silph Scope | Allows you to see Ghost Pokemon. |
| Poke Flute | Wakes up a sleeping Pokemon. |
| Old/Good/Super Rod | Use these to catch Water Pokemon. |
| Item Finder | Helps you find hidden items. |
| Exp. All | Shares Experience with Pokemon that didn't fight. |
| Coin | Use these at the Game Corner. |
| Coin Case | Holds up to 9,999 Game Corner Coins. |
| Fresh Water | Restores HP a little in battle. |
| Soda Pop | Restores some HP in battle. |
| Lemonade | Restores a lot of HP in battle. |
| Fire Stone | Connected to the Fire Pokemon. |
| Thunder Stone | Connected to the Electric Pokemon. |
| Water Stone | Connected to the Water Pokemon. |
| Leaf Stone | Connected to the Grass Pokemon. |
| Moon Stone | Evolution Stone |
| Helix Fossil | Turns into a Pokemon (at Cinnabar Isle) |
| Dome Fossil | Turns into a Pokemon (at Cinnabar Isle) |
| Old Amber | Turns into a Pokemon (at Cinnabar Isle) |